Education
MBBS(Melb), MD(Monash), FRACP, FRCP (Lond, Edin), FHKCP, FHKAM (Medicine), FESC, FACC
Expertise
Interventional Cardiology
Vascular Medicine & Interventions
Research Interests
Percutaneous coronary & endovascular interventions, peripheral arterial disease, atrial fibrillation and health economics.
Prof. Yan graduated from the University of Melbourne in 1998 and received Fellowship from the Australasian College of Physician in the specialty of cardiology in 2005, Fellowship of the Hong Kong College of Physician and Fellow of the American College of Cardiology in 2010, Fellow of the European Society of Cardiology in 2012 and Fellow of the Royal College of Physicians of Edinburgh in 2014. Prof. Yan joined the Department of Medicine & Therapeutics in 2008 after completing a combined clinical and research fellowship in vascular medicine & interventions at the Massachusetts General Hospital, Harvard Medical School, Boston, United States. He has an appointment as Adjunct Associate Professor in the Department of Epidemiology & Preventive Medicine, School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia since 2012.
His major research interests include:
(i) Clinical Epidemiology & Outcome Research: benchmarking local clinical practice and outcomes in cardiovascular disease management using large registries to identify therapeutic gaps to improve clinical decision making, healthcare delivery and patient outcomes, quality-of-life & cost-effectiveness analyses for health interventions
(ii) Ambulatory & remote patient monitoring systems such as high-throughput atrial fibrillation screening and flexible & wearable devices for health informatics
(iii) Advanced endovascular interventions: Intravascular imaging using optical coherence tomography, endovascular procedures for critical limb ischemia & limb preservation and pharmaco-mechanical treatment of acute & chronic thromboembolism
In 2009, he was awarded his first-of-three, Research Grant Council General Research Fund (RGC-GRF) grant (HK$1.1 million) as principal investigator to establish an interventional registry to evaluate the cost-effectiveness of drug-eluting stents in Hong Kong in collaboration with Monash University and established the ASia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Collaboration involving >80,000 patients from more than 30 hospitals across Hong Kong, Singapore, Malaysia and Australia aiming to benchmark outcomes of cardiac interventions across the Asia Pacific region. He has established a unit for large registry data management, analysis and reporting of clinical outcomes for the first multi-center PCI registry in Hong Kong and the multi-national Asia-Pacific CTO Club Registry.
In 2014, He was awarded his third RGC-GRF grant (HK$0.9 million) as principal investigator for a large-scale randomized study to assess the feasibility and cost-effectiveness of targeted screening for atrial fibrillation using a handheld ECG device with automated diagnostics in an outpatient setting in collaboration with the University of Sydney, Australia. The study has completed >23,000 screenings events and novel finding included incremental yield for repeated opportunistic ECG screening was awarded the Best Moderated Poster at the European Society of Cardiology Congress, Barcelona in 2017. Our group was the first in the world to validate a novel contact-free atrial fibrillation screening method by a smartphone camera using facial pulsatile photoplethysmorgraphic (PPG) signals. Our current research direction is to further develop a contact-free high-throughput atrial fibrillation screening method suitable for large-scale community and population screening.
Prof. Yan is a regional leader in the field of interventional cardiology and endovascular treatment of peripheral vascular diseases. In 2010, he was awarded a Young Leadership Award in Interventional Cardiology from the Cardiovascular Research Institute, Washington DC, United States. Upon his return to Hong Kong in 2008, he built the peripheral endovascular program at the Prince of Wales Hospital and currently performs the largest volume of complex endovascular procedures for critical limb ischemia in Hong Kong. He launched the Combined Vascular Medicine & Intervention Services and the Multi-disciplinary Diabetic Foot Clinic in collaboration with vascular surgery, orthopedic surgery, endocrinology and podiatry to fast-track urgent referrals aiming to reduce lower limb amputations. He has given numerous public talks and media interviews to promote awareness of peripheral arterial disease and limb salvage operations. He has been awarded more than HK$3 million from the SK Yee Medical Foundation Grant to provide limb saving endovascular therapy for financially disadvantaged patients with critical and acute limb ischemia in Hong Kong. In 2013, he was awarded HK$1 million by the Health and Medical Research Fund to evaluate the use of traditional Chinese Medicine (Danshen and Gegen) as a novel treatment for peripheral arterial disease as Principal Investigator in collaboration with the CUHK Institute of Chinese Medicine.
Prof. Yan has authored >190 peer reviewed publications (>3,500 citations & h-index of 32), 7 book chapters and >250 abstracts at national and international scientific meetings. He has been invited speaker and chairperson to numerous interventional cardiology meetings in Hong Kong, China, Australia, Japan, Korea, Singapore and Malaysia and has performed live interventional cases for teaching purposes at international meetings.
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